Original Research (Original Article) 


Physicochemical properties and antibacterial efficacy of ciprofloxacin –phenazopyridine drugs in a binary solid dispersion

Mohamed M. Abdulaa, Fahd M. Alsharif, Gamal S. Zayed, Mohamed T. Salem, Yaseen A. Elshaier.

Abstract
Significance
Urinary tract infections (UTIs) are among the most common bacterial infections in humans. Severe pain accompanying UTIs necessitates a combination therapy of antibiotic (ciprofloxacin HCl, CIP‧HCl) with UTI analgesic (phenazopyridine HCl, PHZ‧HCl). However, the physicochemical properties and antibacterial activity of this combination need to be further explored.
Objective
The aim of the present study was to explore the physicochemical properties and antibacterial efficacy of CIP‧HCl-PHZ‧HCl in a binary solid dispersion (SD) system using polyvinylpyrrolidone (PVP).
Methods
The SD was prepared using solvent method. The dissolution of CIP‧HCl was measured. The physical state and solid-state interactions between CIP‧HCl, PHZ‧HCl, PVP and SD were explored using FTIR spectroscopy, 1H-NMR and PXRD. Finally, the minimum inhibitory concentration (MIC) of the prepared SD was compared to pure CIP‧HCl.
Results
Data showed improved dissolution behavior of the prepared SD compared with the pure drug. PXRD showed that CIP‧HCl did not convert into amorphous form with PVP however; a decrease in the intensities was detected probably due to dilution with the polymer. FTIR and 1H-NMR data showed that hydrochloride molecule (HCl) was transferred from the piprezinyl group of CIP‧HCl to PHZ‧HCl. In another anticipated interaction, both carboxylic and ketone functionalities of CIP‧HCl engaged in salt formation and hydrogen bonding with PHZ.

Conclusions
CIP‧HCl antibacterial activity was improved against various pathogens suggesting the ability of CIP‧HCl, in the SD system, to diffuse more through the bacterial cell membrane. Moreover, possible interactions between CIP‧HCl with PHZ‧HCl would help increase the stability of the prepared SD system.

Key words: UTIs, Ciprofloxacin HCl; binary solid dispersion; phenazopyridine HCl; dissolution; antibacterial


 
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How to Cite this Article
Pubmed Style

Abdulaa MM, Alsharif FM, Zayed GS, Salem MT, Elshaier YA. Physicochemical properties and antibacterial efficacy of ciprofloxacin –phenazopyridine drugs in a binary solid dispersion. AJMS. 2018; 1(2): 12-16. doi:10.5455/ajms.9


Web Style

Abdulaa MM, Alsharif FM, Zayed GS, Salem MT, Elshaier YA. Physicochemical properties and antibacterial efficacy of ciprofloxacin –phenazopyridine drugs in a binary solid dispersion. http://www.ajms.tk/?mno=8073 [Access: August 17, 2019]. doi:10.5455/ajms.9


AMA (American Medical Association) Style

Abdulaa MM, Alsharif FM, Zayed GS, Salem MT, Elshaier YA. Physicochemical properties and antibacterial efficacy of ciprofloxacin –phenazopyridine drugs in a binary solid dispersion. AJMS. 2018; 1(2): 12-16. doi:10.5455/ajms.9



Vancouver/ICMJE Style

Abdulaa MM, Alsharif FM, Zayed GS, Salem MT, Elshaier YA. Physicochemical properties and antibacterial efficacy of ciprofloxacin –phenazopyridine drugs in a binary solid dispersion. AJMS. (2018), [cited August 17, 2019]; 1(2): 12-16. doi:10.5455/ajms.9



Harvard Style

Abdulaa, M. M., Alsharif, . F. M., Zayed, . G. S., Salem, . M. T. & Elshaier, . Y. A. (2018) Physicochemical properties and antibacterial efficacy of ciprofloxacin –phenazopyridine drugs in a binary solid dispersion. AJMS, 1 (2), 12-16. doi:10.5455/ajms.9



Turabian Style

Abdulaa, Mohamed M., Fahd M. Alsharif, Gamal S. Zayed, Mohamed T. Salem, and Yaseen A. Elshaier. 2018. Physicochemical properties and antibacterial efficacy of ciprofloxacin –phenazopyridine drugs in a binary solid dispersion. Arabian journal of medical sciences, 1 (2), 12-16. doi:10.5455/ajms.9



Chicago Style

Abdulaa, Mohamed M., Fahd M. Alsharif, Gamal S. Zayed, Mohamed T. Salem, and Yaseen A. Elshaier. "Physicochemical properties and antibacterial efficacy of ciprofloxacin –phenazopyridine drugs in a binary solid dispersion." Arabian journal of medical sciences 1 (2018), 12-16. doi:10.5455/ajms.9



MLA (The Modern Language Association) Style

Abdulaa, Mohamed M., Fahd M. Alsharif, Gamal S. Zayed, Mohamed T. Salem, and Yaseen A. Elshaier. "Physicochemical properties and antibacterial efficacy of ciprofloxacin –phenazopyridine drugs in a binary solid dispersion." Arabian journal of medical sciences 1.2 (2018), 12-16. Print. doi:10.5455/ajms.9



APA (American Psychological Association) Style

Abdulaa, M. M., Alsharif, . F. M., Zayed, . G. S., Salem, . M. T. & Elshaier, . Y. A. (2018) Physicochemical properties and antibacterial efficacy of ciprofloxacin –phenazopyridine drugs in a binary solid dispersion. Arabian journal of medical sciences, 1 (2), 12-16. doi:10.5455/ajms.9